You may think of testosterone as the primary sex hormone in biological men (even though all people need testosterone to function). But what about DHEA? DHEA (dehydroepiandrosterone) is a steroid hormone that men’s bodies produce in the adrenal glands, brain, and testes. From there, it circulates into the bloodstream as dehydroepiandrosterone sulfate (DHEA-S or DHEA-sulfate), where the body converts it into testosterone and other “male” sex hormones called androgens.
UNDERSTANDING DHEA
DHEA contributes to many “male” sexual characteristics that define puberty—oily skin, body odor, and pubic hair growth. However, as we age, levels of DHEA begin to decline. By the time a man is 70–80 years old, his DHEA hormone levels are only 10–20% of what they were when he was younger.
BENEFITS OF DHEA FOR MEN
DHEA supplements have been touted for their potential to enhance sexual function, improve energy, treat adrenal insufficiency, and manage body fat and body composition. However, research on the benefits of DHEA for men has produced mixed results. Large, randomized trials are needed to confirm DHEA’s potential benefits for well-being.
DHEA FOR ERECTILE DYSFUNCTION (ED)
Some small studies have suggested that DHEA can improve erectile dysfunction (ED), making it easier to achieve or maintain an erection. However, more research is needed to confirm these findings.
DHEA FOR MUSCLE BUILDING
According to the NIH’s report on Dietary Supplements for Exercise and Athletic Performance, DHEA has not demonstrated any proven benefit for physical performance in terms of increasing muscle strength, aerobic capacity, lean body mass, or testosterone levels in men.
DHEA FOR OBESITY
Some studies suggest that DHEA may help reduce abdominal fat and insulin resistance, factors linked to type 2 diabetes. However, other studies do not show that DHEA is effective for weight loss and treating obesity.
DHEA FOR IMMUNE FUNCTION
Research on DHEA’s potential impact on the immune system is limited. While some studies have explored its role in immune diseases like Sjogren syndrome, results have not been promising. More research is needed to understand its potential benefits for other immune conditions.
SIDE EFFECTS AND RISKS OF DHEA
DHEA is generally considered safe when taken at regular doses (50 mg per day) for less than two years. However, higher doses or long-term use may lead to side effects such as acne and upset stomach. DHEA supplements may also interact with certain medications and pose risks to individuals with specific health conditions, including depression, bipolar disorder, diabetes, heart disease, liver disease, and prostate cancer.
CONSULTING WITH YOUR HEALTHCARE PROVIDER
Before considering DHEA supplementation, it’s essential to discuss potential benefits, risks, and interactions with your healthcare provider. They can help you make an informed decision based on your individual health needs and circumstances.
CONCLUSION
While DHEA may offer some potential benefits for men’s health, including sexual function and body composition, the research is mixed, and more studies are needed to fully understand its effects. If you’re considering DHEA supplementation, work closely with your healthcare provider to ensure safe and appropriate use.
DISCLAIMER
If you have any medical questions or concerns, please talk to your healthcare provider. The articles on Health Guide are underpinned by peer-reviewed research and information drawn from medical societies and governmental agencies. However, they are not a substitute for professional medical advice, diagnosis, or treatment.”
SOURCES:
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- Orner, G. A., & Mathews, L. J. (2012). Dehydroepiandrosterone replacement for androgen deficiency in aging males. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 23(2), 125-131.
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- Khorram, O., Vu, L., Yen, S. S., & Qiao, L. (1998). Effects of transdermal testosterone gel on bone turnover markers and bone mineral density in hypogonadal men. Clinical Endocrinology, 48(3), 311-317.