Navigating Testosterone Replacement Therapy: Understanding Side Effects and Myths

Testosterone plays a crucial role in various bodily functions, and its decline with age can lead to symptoms of low testosterone (low T). For those grappling with low T, testosterone replacement therapy (TRT) emerges as a potential solution. However, like any medical intervention, TRT comes with its share of side effects and misconceptions. In this guide by Aktwisted Wellness, we delve into the nuances of TRT, exploring its side effects, dispelling myths, and shedding light on important considerations for those considering this treatment option.

 

Many people experience low testosterone (or low T), and testosterone levels naturally decrease as we age. Low T can cause myriad less-than-desirable symptoms, including fatigue, low sex drive, muscle loss, and depression. So It’s no wonder those experiencing low T are eager to find a solution. Testosterone replacement therapy (TRT) is one option to increase testosterone levels and treat the symptoms of low testosterone. But TRT is not without potential side effects. Some TRT side effects include acne, breast growth, and low sperm production. Continue reading to learn more about TRT side effects (and TRT myths).

 

Mild Side Effects of TRT:

Like any medication, those receiving testosterone replacement therapy may experience some mild symptoms. Here are some of the mild symptoms experienced by people receiving TRT:

 

1. Acne: When testosterone levels rise, so does the production of sebum (an oily substance found on the skin). More sebum can sometimes lead to the development or worsening of acne.

 

2. Breast Growth and/or Tenderness: 10–25% of men receiving TRT experience gynecomastia (an increase in breast tissue) and/or breast pain. This imbalance may cause some testosterone to be converted to estrogen through a process called aromatization.

 

3. Water Retention: Water retention, or edema, is a known side effect of TRT. While generally mild, water retention may cause swelling in the hands, legs, ankles, and feet.

 

4. Hair Pattern Changes: Some people receiving TRT have reported changes to their hair patterns. More research is needed to understand this potential side effect.

 

While side effects like acne and hair pattern changes are disruptive, they are generally considered tolerable and low risk.

 

Testosterone and Prostate Cancer:

While TRT does not cause prostate cancer, it has been shown to accelerate the growth of prostate cancer when the cancer is already present. However, many studies investigating testosterone levels and subsequent prostate cancer risk (in men who did not already have prostate cancer) did not find any connection.

 

Testosterone and Heart Disease:

Research on the connection between testosterone and heart health paints a different picture. The most comprehensive meta-analysis found no increase in cardiovascular risks among men receiving TRT, and reduced cardiovascular risks among men with metabolic disease receiving TRT.

 

Testosterone and Sperm Count:

Adding external testosterone into the body causes the brain to slow the release of both LH and FSH, essential for sperm production. Decreased FSH may mean decreased sperm count, negatively impacting fertility.

 

Conclusion:

If you experience symptoms of low T, you’re not alone. Speak with your healthcare provider to find a safe treatment plan that’s right for you.

 

DISCLAIMER:

If you have any medical questions or concerns, please talk to your healthcare provider. The articles on Health Guide are underpinned by peer-reviewed research and information drawn from medical societies and governmental agencies. However, they are not a substitute for professional medical advice, diagnosis, or treatment.

 

Sources:

1. Snyder, P. J., Bhasin, S., Cunningham, G. R., Matsumoto, A. M., Stephens-Shields, A. J., Cauley, J. A., … & Ellenberg, S. S. (2016). Effects of testosterone treatment in older men. New England Journal of Medicine, 374(7), 611-624.
2. Schooling, C. M., Au Yeung, S. L., Freeman, G., Cowling, B. J., & Theodoratou, E. (2016). Testosterone and cardiovascular disease. Heart, 102(23), 1799-1805.
3. Dabaja, A. A., & Wosnitzer, M. S. (2017). Testosterone therapy and prostate cancer. Translational Andrology and Urology, 6(3), 511.
4. Surampudi, P. N., Wang, C., Swerdloff, R., & Wang, C. (2014). An update on male hypogonadism therapy. Expert Opinion on Pharmacotherapy, 15(9), 1247-1264.
5. Allan, C. A., Strauss, B. J., Burger, H. G., Forbes, E. A., & McLachlan, R. I. (2008). Testosterone therapy prevents gain in visceral adipose tissue and loss of skeletal muscle in nonobese aging men. The Journal of Clinical Endocrinology & Metabolism, 93(1), 139-146.